What effect does the mothers’ HIV medication have on the fetus?
The use of HIV medication in pregnancy has been tremendously successful in radically reducing the risk of HIV transmission.
However, the specific risks associated with exposure of the developing fetus to HIV medication during pregnancy are not fully known. Accumulating evidence suggests exposure to ARVs adversely affects fetal and infant development and brain development and function, however, those studies face many unavoidable confounding factors. By using animal models, this study will provide greater clarity by investigating drug toxicities. This study will uncover the impact HIV medication has on fetal and infant development using cellular imaging, behavioural testing, and magnetic resonance imaging.